N-Acetyllactosamine 6,6`-Disulfate Disodium Salt CAS 321897-68-1

FC-152

LacNAc(2S); 2-(Acetylamino)-2-deoxy-4-O-(6-O-sulfo-β-D-galactopyranosyl)-D-glucose 6-(Hydrogen Sulfate) Disodium Salt; Gal(6S)β-(1-4)-GlcNAc(6S)

LacNAc(2S), ≥ 70.0% purity

Used in the screening and diagnosis of Morquio A syndrome (MPS IVA). Validation of an LC-MS/MS assay for detecting relevant disaccharides from keratan sulfate as a biomarker for Morquio A syndrome.^1,2

N-Acetyllactosamine derivatives were tested as acceptors for α1,3-L-Fucosyltransferase present in human ovarian cancer sera and ovarian tumor. ^3-7

1. L.A. Martell et. al. Bioanalysis, 3(16), 1855-1866 (2011)
2. C. Auray-Blais et. al. Bioanalysis, 8(3), 179-191 (2016)
3. Lasky, L. et al.Science, 258, 964 (1992)
4. Hemmerich, S. et al.Biochemistry, 33, 4830 (1994)
5. Clarke, J. et al.J. Biol. Chem., 271, 10317 (1996)
6. Komba, S. et al.Bioorg. Med. Chem., 4, 1833 (1996)
7. Yoshino, K. et al.J. Med. Chem., 40, 455 (1997)

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